6ZPR
Solution structure of MLKL executioner domain in complex with a covalent inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Mixed lineage kinase domain-like protein,Mixed lineage kinase domain-like protein | polymer | 157 | 18185.0 | 1 | UniProt (Q8NB16) In PDB | Homo sapiens (Human) | hMLKL,hMLKL |
| 2 | A | 7-(2-methoxyethoxymethyl)-1,3-dimethyl-purine-2,6-dione | non-polymer | 268.3 | 1 | Chemie (QOK) |
Sequence modifications
A: 2 - 85 (UniProt: Q8NB16)
A: 86 - 154 (UniProt: Q8NB16)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18185.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 268.3 | |
| All* | Total formula weight | 18453.2 |
