6YSQ
The hC4Nb8 complement inhibitory nanobody in complex with C4b
Summary for 6YSQ
| Entry DOI | 10.2210/pdb6ysq/pdb |
| Descriptor | Complement C4 beta chain, Complement C4-A alpha chain, Complement C4 gamma chain, ... (5 entities in total) |
| Functional Keywords | nanobody, inhibitor, complement c4b, immune system |
| Biological source | Escherichia coli More |
| Total number of polymer chains | 8 |
| Total formula weight | 392427.12 |
| Authors | Zarantonello, A.,Laursen, N.S.,Andersen, G.R. (deposition date: 2020-04-23, release date: 2020-06-24, Last modification date: 2024-01-24) |
| Primary citation | Zarantonello, A.,Presumey, J.,Simoni, L.,Yalcin, E.,Fox, R.,Hansen, A.,Olesen, H.G.,Thiel, S.,Johnson, M.B.,Stevens, B.,Laursen, N.S.,Carroll, M.C.,Andersen, G.R. An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase. J Immunol., 205:1678-1694, 2020 Cited by PubMed: 32769120DOI: 10.4049/jimmunol.2000528 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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