6Y6O

Structure of mature activin A with small molecule 42

Summary for 6Y6O

• Entry DOI: 10.2210/pdb6y6o/pdb
• Descriptor: Inhibin beta A chain, SULFATE ION, (3~{R})-4-ethyl-3-methyl-3-propyl-1~{H}-1,4-benzodiazepine-2,5-dione, ... (4 entities in total)
• Functional Keywords: activin a, tgf-beta, growth factor, fbdd, inhibitor, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 26724.38

Authors

McLoughlin, J.D.,Brear, P.B.,Reinhardt, T.,Spring, D.R.,Hyvonen, M. (deposition date: 2020-02-26, release date: 2021-02-03, Last modification date: 2024-01-24)

• Primary citation: Kidd, S.L.,Fowler, E.,Reinhardt, T.,Compton, T.,Mateu, N.,Newman, H.,Bellini, D.,Talon, R.,McLoughlin, J.,Krojer, T.,Aimon, A.,Bradley, A.,Fairhead, M.,Brear, P.,Diaz-Saez, L.,McAuley, K.,Sore, H.F.,Madin, A.,O'Donovan, D.H.,Huber, K.V.M.,Hyvonen, M.,Dowson, C.G.,Spring, D.R.; Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion; Chem Sci, 11:10792-10801, 2020; DOI: 10.1039/D0SC01232G

Experimental method

X-RAY DIFFRACTION (2.04 Å)