6X6C

Cryo-EM structure of NLRP1-DPP9-VbP complex

Summary for 6X6C

• Entry DOI: 10.2210/pdb6x6c/pdb
• EMDB information: 22075
• Descriptor: Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1, [(2~{R})-1-[(2~{R})-2-azanyl-3-methyl-butanoyl]pyrrolidin-2-yl]boronic acid (3 entities in total)
• Functional Keywords: nlrp1, dpp9, inflammasome, val-boropro (vbp), talabostat, innate immunity, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 536091.08

Authors

Hollingsworth, L.R.,Sharif, H.,Griswold, A.R.,Fontana, P.,Mintseris, J.,Dagbay, K.B.,Paulo, J.A.,Gygi, S.P.,Bachovchin, D.A.,Wu, H. (deposition date: 2020-05-27, release date: 2021-03-10, Last modification date: 2021-05-12)

• Primary citation: Hollingsworth, L.R.,Sharif, H.,Griswold, A.R.,Fontana, P.,Mintseris, J.,Dagbay, K.B.,Paulo, J.A.,Gygi, S.P.,Bachovchin, D.A.,Wu, H.; DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.; Nature, 592:778-783, 2021; PubMed: 33731932; DOI: 10.1038/s41586-021-03350-4

Experimental method

ELECTRON MICROSCOPY (2.9 Å)