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6X6C

Cryo-EM structure of NLRP1-DPP9-VbP complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0004177molecular_functionaminopeptidase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005874cellular_componentmicrotubule
A0006508biological_processproteolysis
A0008236molecular_functionserine-type peptidase activity
A0008239molecular_functiondipeptidyl-peptidase activity
A0031252cellular_componentcell leading edge
A0042802molecular_functionidentical protein binding
A0043069biological_processnegative regulation of programmed cell death
A0070269biological_processpyroptosis
D0004177molecular_functionaminopeptidase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005874cellular_componentmicrotubule
D0006508biological_processproteolysis
D0008236molecular_functionserine-type peptidase activity
D0008239molecular_functiondipeptidyl-peptidase activity
D0031252cellular_componentcell leading edge
D0042802molecular_functionidentical protein binding
D0043069biological_processnegative regulation of programmed cell death
D0070269biological_processpyroptosis
E0002221biological_processpattern recognition receptor signaling pathway
E0003690molecular_functiondouble-stranded DNA binding
E0003725molecular_functiondouble-stranded RNA binding
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005730cellular_componentnucleolus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006508biological_processproteolysis
E0006915biological_processapoptotic process
E0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
E0006954biological_processinflammatory response
E0007165biological_processsignal transduction
E0008233molecular_functionpeptidase activity
E0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
E0012501biological_processprogrammed cell death
E0016887molecular_functionATP hydrolysis activity
E0019899molecular_functionenzyme binding
E0019904molecular_functionprotein domain specific binding
E0032495biological_processresponse to muramyl dipeptide
E0032731biological_processpositive regulation of interleukin-1 beta production
E0035591molecular_functionsignaling adaptor activity
E0038187molecular_functionpattern recognition receptor activity
E0042742biological_processdefense response to bacterium
E0042981biological_processregulation of apoptotic process
E0045087biological_processinnate immune response
E0050727biological_processregulation of inflammatory response
E0050729biological_processpositive regulation of inflammatory response
E0051260biological_processprotein homooligomerization
E0051402biological_processneuron apoptotic process
E0051607biological_processdefense response to virus
E0061702cellular_componentcanonical inflammasome complex
E0070269biological_processpyroptosis
E0071493biological_processcellular response to UV-B
E0072558cellular_componentNLRP1 inflammasome complex
E0097264biological_processself proteolysis
E0140374biological_processantiviral innate immune response
E0140608molecular_functioncysteine-type endopeptidase activator activity
E0140693molecular_functionmolecular condensate scaffold activity
E1904784biological_processNLRP1 inflammasome complex assembly
F0002221biological_processpattern recognition receptor signaling pathway
F0003690molecular_functiondouble-stranded DNA binding
F0003725molecular_functiondouble-stranded RNA binding
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006508biological_processproteolysis
F0006915biological_processapoptotic process
F0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
F0006954biological_processinflammatory response
F0007165biological_processsignal transduction
F0008233molecular_functionpeptidase activity
F0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
F0012501biological_processprogrammed cell death
F0016887molecular_functionATP hydrolysis activity
F0019899molecular_functionenzyme binding
F0019904molecular_functionprotein domain specific binding
F0032495biological_processresponse to muramyl dipeptide
F0032731biological_processpositive regulation of interleukin-1 beta production
F0035591molecular_functionsignaling adaptor activity
F0038187molecular_functionpattern recognition receptor activity
F0042742biological_processdefense response to bacterium
F0042981biological_processregulation of apoptotic process
F0045087biological_processinnate immune response
F0050727biological_processregulation of inflammatory response
F0050729biological_processpositive regulation of inflammatory response
F0051260biological_processprotein homooligomerization
F0051402biological_processneuron apoptotic process
F0051607biological_processdefense response to virus
F0061702cellular_componentcanonical inflammasome complex
F0070269biological_processpyroptosis
F0071493biological_processcellular response to UV-B
F0072558cellular_componentNLRP1 inflammasome complex
F0097264biological_processself proteolysis
F0140374biological_processantiviral innate immune response
F0140608molecular_functioncysteine-type endopeptidase activator activity
F0140693molecular_functionmolecular condensate scaffold activity
F1904784biological_processNLRP1 inflammasome complex assembly
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00136
ChainResidueDetails
EGLY334
FGLY334

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: (Microbial infection) Cleavage; by human rhinovirus 14 (HRV-14) Protease 3C => ECO:0000269|PubMed:33093214, ECO:0000269|PubMed:33410748
ChainResidueDetails
DASP808
DHIS840
EGLN130
FGLN130

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: (Microbial infection) Cleavage; by coronavirus SARS-CoV-2 proteinase nsp5 => ECO:0000269|PubMed:35594856
ChainResidueDetails
EGLN333
FGLN333

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Cleavage; by autolysis => ECO:0000255|PROSITE-ProRule:PRU01174, ECO:0000269|PubMed:22665479
ChainResidueDetails
EPHE1212
FPHE1212

site_idSWS_FT_FI5
Number of Residues8
DetailsMOD_RES: Phosphoserine; by MAPK11 and MAPK14 => ECO:0000269|PubMed:35857590
ChainResidueDetails
ESER93
ESER99
ESER101
ESER170
FSER93
FSER99
FSER101
FSER170

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine; by MAPK14 => ECO:0000269|PubMed:35857590
ChainResidueDetails
ESER107
ESER163
FSER107
FSER163

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by MAPK11, MAPK14 and MAP3K20 => ECO:0000269|PubMed:35857590
ChainResidueDetails
ETHR112
FTHR112

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphoserine; by MAP3K20 => ECO:0000269|PubMed:35857590
ChainResidueDetails
ESER113
ESER132
FSER113
FSER132

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by MAP3K20 => ECO:0000269|PubMed:35857590
ChainResidueDetails
ETHR114
ETHR129
FTHR114
FTHR129

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAPK11 and MAPk14 => ECO:0000269|PubMed:35857590
ChainResidueDetails
ESER168
FSER168

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAPK11 => ECO:0000269|PubMed:35857590
ChainResidueDetails
ESER173
FSER173

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by MAPK11 => ECO:0000269|PubMed:35857590
ChainResidueDetails
ETHR178
FTHR178

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAPK11 and MAP3K20 => ECO:0000269|PubMed:35857590
ChainResidueDetails
ESER179
FSER179

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by MAPK11 and MAP3K20 => ECO:0000269|PubMed:35857590
ChainResidueDetails
ETHR180
FTHR180

219869

PDB entries from 2024-05-15

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