6WSJ

Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with cyclopeptide des4.3.1

Summary for 6WSJ

• Entry DOI: 10.2210/pdb6wsj/pdb
• Related PRD ID: PRD_002383
• Descriptor: Hdac6 protein, cyclopeptide des4.3.1, ZINC ION, ... (6 entities in total)
• Functional Keywords: hydrolase, histone deacetylase, inhibitor, metallohydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Danio rerio (Zebrafish); More
• Total number of polymer chains: 2
• Total formula weight: 41550.44

Authors

Watson, P.R.,Christianson, D.W. (deposition date: 2020-05-01, release date: 2021-04-28, Last modification date: 2023-11-15)

• Primary citation: Hosseinzadeh, P.,Watson, P.R.,Craven, T.W.,Li, X.,Rettie, S.,Pardo-Avila, F.,Bera, A.K.,Mulligan, V.K.,Lu, P.,Ford, A.S.,Weitzner, B.D.,Stewart, L.J.,Moyer, A.P.,Di Piazza, M.,Whalen, J.G.,Greisen, P.J.,Christianson, D.W.,Baker, D.; Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites.; Nat Commun, 12:3384-3384, 2021; PubMed: 34099674; DOI: 10.1038/s41467-021-23609-8

Experimental method

X-RAY DIFFRACTION (1.7 Å)