6W3H

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

Summary for 6W3H

• Entry DOI: 10.2210/pdb6w3h/pdb
• Descriptor: ATV Fc, Transferrin receptor protein 1,Transferrin receptor protein 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: blood-brain barrier, transferrin binding receptor, antibody transport vehicle, protein transport
• Biological source: Homo sapiens; More
• Total number of polymer chains: 4
• Total formula weight: 88381.44

Authors

Srivastava, A.,Kariolis, M.,Wells, R. (deposition date: 2020-03-09, release date: 2020-06-10, Last modification date: 2023-10-18)

• Primary citation: Kariolis, M.S.,Wells, R.C.,Getz, J.A.,Kwan, W.,Mahon, C.S.,Tong, R.,Kim, D.J.,Srivastava, A.,Bedard, C.,Henne, K.R.,Giese, T.,Assimon, V.A.,Chen, X.,Zhang, Y.,Solanoy, H.,Jenkins, K.,Sanchez, P.E.,Kane, L.,Miyamoto, T.,Chew, K.S.,Pizzo, M.E.,Liang, N.,Calvert, M.E.K.,DeVos, S.L.,Baskaran, S.,Hall, S.,Sweeney, Z.K.,Thorne, R.G.,Watts, R.J.,Dennis, M.S.,Silverman, A.P.,Zuchero, Y.J.Y.; Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys.; Sci Transl Med, 12:-, 2020; PubMed: 32461332; DOI: 10.1126/scitranslmed.aay1359

Experimental method

X-RAY DIFFRACTION (3.38 Å)