6W3H
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | ATV Fc | polymer | 227 | 25578.8 | 2 | Homo sapiens | ||
2 | C, D | Transferrin receptor protein 1,Transferrin receptor protein 1 | polymer | 166 | 17953.3 | 2 | UniProt (P02786) Pfam (PF02225) In PDB | Homo sapiens (Human) | Trfr,T9,p90,Trfr,T9,p90 |
3 | E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1317.2 | 1 | In PDB GlyTouCan (G39213VZ) |
Sequence modifications
C, D: 22 - 75 (UniProt: P02786)
C, D: 76 - 178 (UniProt: P02786)
PDB | External Database | Details |
---|---|---|
Thr 21 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ala 179 | - | linker |
Ser 180 | - | linker |
His 181 | - | expression tag |
His 182 | - | expression tag |
His 183 | - | expression tag |
His 184 | - | expression tag |
His 185 | - | expression tag |
His 186 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 87064.2 | |
Branched | Number of molecules | 1 |
Total formula weight | 1317.2 | |
All* | Total formula weight | 88381.4 |