6VNH

JAK2 JH1 in complex with PN2-123

Summary for 6VNH

Entry DOI	10.2210/pdb6vnh/pdb
Descriptor	Tyrosine-protein kinase JAK2, N-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-2-methylpropane-2-sulfonamide (3 entities in total)
Functional Keywords	janus associated kinase, jak2, kinase domain, jh1, kinase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	74036.18
Authors	Davis, R.R.,Schonbrunn, E. (deposition date: 2020-01-29, release date: 2021-02-17, Last modification date: 2023-11-15)
Primary citation	Davis, R.R.,Li, B.,Yun, S.Y.,Chan, A.,Nareddy, P.,Gunawan, S.,Ayaz, M.,Lawrence, H.R.,Reuther, G.W.,Lawrence, N.J.,Schonbrunn, E. Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof. J.Med.Chem., 64:2228-2241, 2021 Cited by PubMed: 33570945 DOI: 10.1021/acs.jmedchem.0c01952 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation