6VNH
JAK2 JH1 in complex with PN2-123
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A | Tyrosine-protein kinase JAK2 | polymer | 308 | 36455.4 | 2 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
2 | B, A | N-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-2-methylpropane-2-sulfonamide | non-polymer | 562.6 | 2 | Chemie (XZS) | |||
3 | water | water | 18.0 | 42 | Chemie (HOH) |
Sequence modifications
B, A: 840 - 1132 (UniProt: O60674)
PDB | External Database | Details |
---|---|---|
His 825 | - | expression tag |
His 826 | - | expression tag |
His 827 | - | expression tag |
His 828 | - | expression tag |
His 829 | - | expression tag |
His 830 | - | expression tag |
His 831 | - | expression tag |
His 832 | - | expression tag |
Glu 833 | - | expression tag |
Asn 834 | - | expression tag |
Leu 835 | - | expression tag |
Tyr 836 | - | expression tag |
Phe 837 | - | expression tag |
Gln 838 | - | expression tag |
Gly 839 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 72910.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1125.3 | |
All* | Total formula weight | 74036.2 |