6V7N

Crystal Structure of a human Lysosome Resident Glycoprotein, Lysosomal Acid Lipase, and its Implications in Cholesteryl Ester Storage Disease (CESD)

Summary for 6V7N

• Entry DOI: 10.2210/pdb6v7n/pdb
• Descriptor: Lysosomal acid lipase/cholesteryl ester hydrolase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: lysosomal acid lipase, cholesteryl ester storage disease, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 89239.68

Authors

Han, S. (deposition date: 2019-12-09, release date: 2020-06-17, Last modification date: 2023-10-11)

• Primary citation: Rajamohan, F.,Reyes, A.R.,Tu, M.,Nedoma, N.L.,Hoth, L.R.,Schwaid, A.G.,Kurumbail, R.G.,Ward, J.,Han, S.; Crystal structure of human lysosomal acid lipase and its implications in cholesteryl ester storage disease.; J.Lipid Res., 61:1192-1202, 2020; PubMed: 32482718; DOI: 10.1194/jlr.RA120000748

Experimental method

X-RAY DIFFRACTION (2.62 Å)