6V7N

Crystal Structure of a human Lysosome Resident Glycoprotein, Lysosomal Acid Lipase, and its Implications in Cholesteryl Ester Storage Disease (CESD)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016788	molecular_function	hydrolase activity, acting on ester bonds
B	0016788	molecular_function	hydrolase activity, acting on ester bonds

Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VYYVGHSQGT

Chain	Residue	Details
A	VAL147-THR156

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU10037

Chain	Residue	Details
B	SER153
B	HIS353
A	SER153
A	HIS353

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site_id	SWS_FT_FI2
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	GLN80
B	ASN252
A	ASN252
B	ASN15
B	GLN51
A	ASN15
A	GLN51
A	GLN80

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASN140
A	GLN300
B	ASN140
B	GLN300

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