6UUI

Crystal structure of the heterocomplex between coil 2B domains of wild-type keratin 1 (KRT1) and keratin 10 (KRT10) containing mutation Cys401Ala

Summary for 6UUI

• Entry DOI: 10.2210/pdb6uui/pdb
• Related: 4ZRY
• Descriptor: Keratin, type II cytoskeletal 1, Keratin, type I cytoskeletal 10, octyl beta-D-glucopyranoside, ... (5 entities in total)
• Functional Keywords: intermediate filament, cytoskeleton, skin, coiled-coil, protein fibril
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 28337.38

Authors

Lomakin, I.B.,Bunick, C.G. (deposition date: 2019-10-30, release date: 2019-11-13, Last modification date: 2023-10-11)

• Primary citation: Lomakin, I.B.,Hinbest, A.J.,Ho, M.,Eldirany, S.A.,Bunick, C.G.; Crystal Structure of Keratin 1/10(C401A) 2B Heterodimer Demonstrates a Proclivity for the C-Terminus of Helix 2B to Form Higher Order Molecular Contacts.; Yale J Biol Med, 93:3-17, 2020; PubMed: 32226330

Experimental method

X-RAY DIFFRACTION (2.069 Å)