6UNS

Kinase domain of ALK2-K492A/K493A with LDN-193189

Summary for 6UNS

• Entry DOI: 10.2210/pdb6uns/pdb
• Related: 6UNQ 6UNR
• Descriptor: Activin receptor type-1, 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline (3 entities in total)
• Functional Keywords: kinase, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 76931.64

Authors

Agnew, C.,Jura, N. (deposition date: 2019-10-13, release date: 2021-07-07, Last modification date: 2023-10-11)

• Primary citation: Agnew, C.,Ayaz, P.,Kashima, R.,Loving, H.S.,Ghatpande, P.,Kung, J.E.,Underbakke, E.S.,Shan, Y.,Shaw, D.E.,Hata, A.,Jura, N.; Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization.; Nat Commun, 12:4950-4950, 2021; PubMed: 34400635; DOI: 10.1038/s41467-021-25248-5

Experimental method

X-RAY DIFFRACTION (2.3 Å)