6UNS
Kinase domain of ALK2-K492A/K493A with LDN-193189
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Activin receptor type-1 | polymer | 330 | 38059.3 | 2 | UniProt (Q04771) Pfam (PF07714) In PDB | Homo sapiens (Human) | Activin receptor type I,ACTR-I,Activin receptor-like kinase 2,ALK-2,Serine/threonine-protein kinase receptor R1,SKR1,TGF-B superfamily receptor type I,TSR-I |
2 | A, B | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | non-polymer | 406.5 | 2 | Chemie (LDN) | |||
3 | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A, B: 201 - 499 (UniProt: Q04771)
PDB | External Database | Details |
---|---|---|
Met 170 | - | initiating methionine |
Ser 171 | - | expression tag |
Tyr 172 | - | expression tag |
Tyr 173 | - | expression tag |
His 174 | - | expression tag |
His 175 | - | expression tag |
His 176 | - | expression tag |
His 177 | - | expression tag |
His 178 | - | expression tag |
His 179 | - | expression tag |
His 180 | - | expression tag |
His 181 | - | expression tag |
His 182 | - | expression tag |
His 183 | - | expression tag |
Asp 184 | - | expression tag |
Tyr 185 | - | expression tag |
Asp 186 | - | expression tag |
Ile 187 | - | expression tag |
Pro 188 | - | expression tag |
Thr 189 | - | expression tag |
Thr 190 | - | expression tag |
Glu 191 | - | expression tag |
Asn 192 | - | expression tag |
Leu 193 | - | expression tag |
Tyr 194 | - | expression tag |
Phe 195 | - | expression tag |
Gln 196 | - | expression tag |
Gly 197 | - | expression tag |
Ala 198 | - | expression tag |
Met 199 | - | expression tag |
Gly 200 | - | expression tag |
Ala 492 | Lys 492 | engineered mutation |
Ala 493 | Lys 493 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 76118.7 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 813.0 | |
All* | Total formula weight | 76931.6 |