6U2H

BRAF dimer bound to 14-3-3

Summary for 6U2H

• Entry DOI: 10.2210/pdb6u2h/pdb
• Related: 6U2G
• Descriptor: 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf, 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, ... (4 entities in total)
• Functional Keywords: braf, 14-3-3, kinase, complex, signaling protein, signaling protein-transferase complex, signaling protein/transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 119764.23

Authors

Liau, N.P.D.,Hymowitz, S.G.,Sudhamsu, J. (deposition date: 2019-08-19, release date: 2019-08-28, Last modification date: 2023-10-11)

• Primary citation: Liau, N.P.D.,Wendorff, T.J.,Quinn, J.G.,Steffek, M.,Phung, W.,Liu, P.,Tang, J.,Irudayanathan, F.J.,Izadi, S.,Shaw, A.S.,Malek, S.,Hymowitz, S.G.,Sudhamsu, J.; Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization.; Nat.Struct.Mol.Biol., 27:134-141, 2020; PubMed: 31988522; DOI: 10.1038/s41594-019-0365-0

Experimental method

X-RAY DIFFRACTION (2.5 Å)