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6U2H

BRAF dimer bound to 14-3-3

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001525biological_processangiogenesis
A0003016biological_processrespiratory system process
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005925cellular_componentfocal adhesion
A0006468biological_processprotein phosphorylation
A0006605biological_processprotein targeting
A0007165biological_processsignal transduction
A0008039biological_processsynaptic target recognition
A0008104biological_processprotein localization
A0019901molecular_functionprotein kinase binding
A0019904molecular_functionprotein domain specific binding
A0030324biological_processlung development
A0031625molecular_functionubiquitin protein ligase binding
A0031647biological_processregulation of protein stability
A0031982cellular_componentvesicle
A0035148biological_processtube formation
A0042149biological_processcellular response to glucose starvation
A0042470cellular_componentmelanosome
A0042802molecular_functionidentical protein binding
A0043066biological_processnegative regulation of apoptotic process
A0043067biological_processregulation of programmed cell death
A0044325molecular_functiontransmembrane transporter binding
A0045296molecular_functioncadherin binding
A0045824biological_processnegative regulation of innate immune response
A0050815molecular_functionphosphoserine residue binding
A0051683biological_processestablishment of Golgi localization
A0070062cellular_componentextracellular exosome
A0070371biological_processERK1 and ERK2 cascade
A0070372biological_processregulation of ERK1 and ERK2 cascade
A0072562cellular_componentblood microparticle
A0090128biological_processregulation of synapse maturation
A0090168biological_processGolgi reassembly
A0098686cellular_componenthippocampal mossy fiber to CA3 synapse
A0098978cellular_componentglutamatergic synapse
A0140297molecular_functionDNA-binding transcription factor binding
A0140311molecular_functionprotein sequestering activity
A1900181biological_processnegative regulation of protein localization to nucleus
A1904262biological_processnegative regulation of TORC1 signaling
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001525biological_processangiogenesis
B0003016biological_processrespiratory system process
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005925cellular_componentfocal adhesion
B0006468biological_processprotein phosphorylation
B0006605biological_processprotein targeting
B0007165biological_processsignal transduction
B0008039biological_processsynaptic target recognition
B0008104biological_processprotein localization
B0019901molecular_functionprotein kinase binding
B0019904molecular_functionprotein domain specific binding
B0030324biological_processlung development
B0031625molecular_functionubiquitin protein ligase binding
B0031647biological_processregulation of protein stability
B0031982cellular_componentvesicle
B0035148biological_processtube formation
B0042149biological_processcellular response to glucose starvation
B0042470cellular_componentmelanosome
B0042802molecular_functionidentical protein binding
B0043066biological_processnegative regulation of apoptotic process
B0043067biological_processregulation of programmed cell death
B0044325molecular_functiontransmembrane transporter binding
B0045296molecular_functioncadherin binding
B0045824biological_processnegative regulation of innate immune response
B0050815molecular_functionphosphoserine residue binding
B0051683biological_processestablishment of Golgi localization
B0070062cellular_componentextracellular exosome
B0070371biological_processERK1 and ERK2 cascade
B0070372biological_processregulation of ERK1 and ERK2 cascade
B0072562cellular_componentblood microparticle
B0090128biological_processregulation of synapse maturation
B0090168biological_processGolgi reassembly
B0098686cellular_componenthippocampal mossy fiber to CA3 synapse
B0098978cellular_componentglutamatergic synapse
B0140297molecular_functionDNA-binding transcription factor binding
B0140311molecular_functionprotein sequestering activity
B1900181biological_processnegative regulation of protein localization to nucleus
B1904262biological_processnegative regulation of TORC1 signaling
C0004672molecular_functionprotein kinase activity
C0005524molecular_functionATP binding
C0006468biological_processprotein phosphorylation
D0004672molecular_functionprotein kinase activity
D0005524molecular_functionATP binding
D0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue 29L C 801
ChainResidue
CILE463
CASP594
CSER465
CVAL471
CLYS483
CGLU501
CTHR529
CTRP531
CCYS532
CPHE583

site_idAC2
Number of Residues8
Detailsbinding site for residue 29L D 801
ChainResidue
DVAL471
DLYS483
DGLU501
DTHR529
DTRP531
DCYS532
DASN580
DPHE583

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues21
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGTVYkGkwhgd.............VAVK
ChainResidueDetails
CILE463-LYS483

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKsnNIFL
ChainResidueDetails
CILE572-LEU584

site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
AARG41-VAL51

site_idPS00797
Number of Residues20
Details1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS
ChainResidueDetails
ATYR211-SER230

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
CASP576
DASP576
BARG56
BARG127

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
CILE463
CLYS483
DILE463
DLYS483

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
CSER447
DSER447
BLYS3
BLYS68

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:21917714
ChainResidueDetails
CARG671
DARG671

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|Ref.8, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
CSEP729
DSEP729

site_idSWS_FT_FI6
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23907581
ChainResidueDetails
CLYS578
BSER207
DLYS578

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P63102
ChainResidueDetails
ASER210
BSER210

220113

PDB entries from 2024-05-22

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