6TV3

HumRadA1 in complex with 3-amino-2-naphthoic acid

Summary for 6TV3

Entry DOI	10.2210/pdb6tv3/pdb
Descriptor	DNA repair and recombination protein RadA, 3-azanylnaphthalene-2-carboxylic acid, PHOSPHATE ION, ... (5 entities in total)
Functional Keywords	rad51, recombinase, dna repair, dna binding protein
Biological source	Pyrococcus furiosus
Total number of polymer chains	1
Total formula weight	25968.50
Authors	Marsh, M.E.,Hyvonen, M. (deposition date: 2020-01-08, release date: 2021-01-27, Last modification date: 2024-01-24)
Primary citation	Scott, D.E.,Francis-Newton, N.J.,Marsh, M.E.,Coyne, A.G.,Fischer, G.,Moschetti, T.,Bayly, A.R.,Sharpe, T.D.,Haas, K.T.,Barber, L.,Valenzano, C.R.,Srinivasan, R.,Huggins, D.J.,Lee, M.,Emery, A.,Hardwick, B.,Ehebauer, M.,Dagostin, C.,Esposito, A.,Pellegrini, L.,Perrior, T.,McKenzie, G.,Blundell, T.L.,Hyvonen, M.,Skidmore, J.,Venkitaraman, A.R.,Abell, C. A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. Cell Chem Biol, 28:835-, 2021 Cited by PubMed: 33662256 DOI: 10.1016/j.chembiol.2021.02.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation