6TCY

X-ray structure of Danio rerio histone deacetylase 6 (HDAC6) CD2 in complex with a inhibitor SS555

This is a non-PDB format compatible entry.

Summary for 6TCY

• Entry DOI: 10.2210/pdb6tcy/pdb
• Descriptor: Histone deacetylase 6, DIMETHYL SULFOXIDE, ZINC ION, ... (11 entities in total)
• Functional Keywords: protein deacetylase, histone deacetylase 6, zinc-binding, isoxazole-2 3-hydroxamate analogues, hydrolase
• Biological source: Danio rerio (Zebrafish)
• Total number of polymer chains: 2
• Total formula weight: 81738.80

Authors

Stransky, J.,Barinka, C. (deposition date: 2019-11-06, release date: 2020-11-04, Last modification date: 2024-01-24)

• Primary citation: Noonepalle, S.,Shen, S.,Ptacek, J.,Tavares, M.T.,Zhang, G.,Stransky, J.,Pavlicek, J.,Ferreira, G.M.,Hadley, M.,Pelaez, G.,Barinka, C.,Kozikowski, A.P.,Villagra, A.; Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models.; J.Med.Chem., 63:10246-10262, 2020; PubMed: 32815366; DOI: 10.1021/acs.jmedchem.0c00567

Experimental method

X-RAY DIFFRACTION (1.6 Å)