6Q38

The Crystal structure of CK2a bound to P1-C4

This is a non-PDB format compatible entry.

Summary for 6Q38

• Entry DOI: 10.2210/pdb6q38/pdb
• Related PRD ID: PRD_002559
• Descriptor: Casein kinase II subunit alpha, Stapled Peptide, BENZOIC ACID, ... (5 entities in total)
• Functional Keywords: ck2alpha, ck2a, stapled peptides, high concentration screening, selective atp competitive inhibitors, surface entrophy reduction, peptide binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 40870.57

Authors

Brear, P.,Iegre, J.,Baker, D.,Tan, Y.,Sore, H.,Donovan, D.,Spring, D.,Chandra, V.,Hyvonen, M. (deposition date: 2018-12-03, release date: 2019-04-24, Last modification date: 2024-03-06)

• Primary citation: Iegre, J.,Brear, P.,Baker, D.J.,Tan, Y.S.,Atkinson, E.L.,Sore, H.F.,O' Donovan, D.H.,Verma, C.S.,Hyvonen, M.,Spring, D.R.; Efficient development of stable and highly functionalised peptides targeting the CK2 alpha /CK2 beta protein-protein interaction.; Chem Sci, 10:5056-5063, 2019; PubMed: 31183056; DOI: 10.1039/c9sc00798a

Experimental method

X-RAY DIFFRACTION (1.74 Å)