6NR0

SIRT2(56-356) with covalent intermediate between mechanism-based inhibitor Glucose-TM-1beta and 1'-SH ADP-ribose

Summary for 6NR0

Entry DOI	10.2210/pdb6nr0/pdb
Descriptor	NAD-dependent protein deacetylase sirtuin-2, ZINC ION, N~2~-[3-(2-hydroxyethoxy)propanoyl]-N-phenyl-N~6~-tetradecanethioyl-L-lysinamide, ... (8 entities in total)
Functional Keywords	inhibitor, intermediate, deacylase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	75381.14
Authors	Price, I.R.,Hong, J. (deposition date: 2019-01-22, release date: 2020-01-22, Last modification date: 2023-10-11)
Primary citation	Hong, J.Y.,Price, I.R.,Bai, J.J.,Lin, H. A Glycoconjugated SIRT2 Inhibitor with Aqueous Solubility Allows Structure-Based Design of SIRT2 Inhibitors. Acs Chem.Biol., 14:1802-1810, 2019 Cited by PubMed: 31373792 DOI: 10.1021/acschembio.9b00384 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation