6NEL

4-(2-(4-fluorophenyl)-5-hydroxy-6-oxo-1,6-dihydropyridin-3-yl)benzoic acid bound to influenza 2009 pH1N1 endonuclease

Summary for 6NEL

Entry DOI	10.2210/pdb6nel/pdb
Descriptor	Polymerase acidic protein, MANGANESE (II) ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	influenza endonuclease inhibitor chelator, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
Biological source	Influenza A virus (A/Luxembourg/43/2009(H1N1))
Total number of polymer chains	1
Total formula weight	29060.81
Authors	Bauman, J.D.,Arnold, E. (deposition date: 2018-12-17, release date: 2019-05-01, Last modification date: 2023-10-11)
Primary citation	Sagong, H.Y.,Bauman, J.D.,Nogales, A.,Martinez-Sobrido, L.,Arnold, E.,LaVoie, E.J. Aryl and Arylalkyl Substituted 3-Hydroxypyridin-2(1H)-ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease. Chemmedchem, 14:1204-1223, 2019 Cited by PubMed: 30983160 DOI: 10.1002/cmdc.201900084 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation