6MUV

The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators

Summary for 6MUV

• Entry DOI: 10.2210/pdb6muv/pdb
• Related: 6DFK 6MUW 6MUX
• EMDB information: 9257 9258 9259
• Descriptor: 20S proteasome alpha-1 subunit, 20S proteasome beta-3 subunit, 20S proteasome beta-4 subunit, ... (15 entities in total)
• Functional Keywords: proteasome, protease, hydrolase, 11s subunit, hydrolyse activator, proteasome activator, complex
• Biological source: Plasmodium falciparum (isolate 3D7); More
• Total number of polymer chains: 42
• Total formula weight: 1227393.13

Authors

Metcalfe, R.D.,Xie, S.C.,Hanssen, E.,Gillett, D.L.,Leis, A.P.,Tilley, L.,Griffin, M.D.W. (deposition date: 2018-10-23, release date: 2019-08-07, Last modification date: 2024-03-13)

• Primary citation: Xie, S.C.,Metcalfe, R.D.,Hanssen, E.,Yang, T.,Gillett, D.L.,Leis, A.P.,Morton, C.J.,Kuiper, M.J.,Parker, M.W.,Spillman, N.J.,Wong, W.,Tsu, C.,Dick, L.R.,Griffin, M.D.W.,Tilley, L.; The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis.; Nat Microbiol, 4:1990-2000, 2019; PubMed: 31384003; DOI: 10.1038/s41564-019-0524-4

Experimental method

ELECTRON MICROSCOPY (3.8 Å)