6KMZ

caspase-4 P22/P10 C258A in complex with human GSDMD-C domain

Summary for 6KMZ

• Entry DOI: 10.2210/pdb6kmz/pdb
• Descriptor: Caspase-4, Gasdermin-D, ... (4 entities in total)
• Functional Keywords: pyroptosis, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 10
• Total formula weight: 167277.57

Authors

Ding, J.,Sun, Q. (deposition date: 2019-08-01, release date: 2020-03-11, Last modification date: 2023-11-22)

• Primary citation: Wang, K.,Sun, Q.,Zhong, X.,Zeng, M.,Zeng, H.,Shi, X.,Li, Z.,Wang, Y.,Zhao, Q.,Shao, F.,Ding, J.; Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis.; Cell, 180:941-, 2020; PubMed: 32109412; DOI: 10.1016/j.cell.2020.02.002

Experimental method

X-RAY DIFFRACTION (3.61 Å)