6KMZ

caspase-4 P22/P10 C258A in complex with human GSDMD-C domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0006508	biological_process	proteolysis
C	0008234	molecular_function	cysteine-type peptidase activity
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0006508	biological_process	proteolysis
D	0008234	molecular_function	cysteine-type peptidase activity
a	0004197	molecular_function	cysteine-type endopeptidase activity
a	0006508	biological_process	proteolysis
a	0008234	molecular_function	cysteine-type peptidase activity
b	0004197	molecular_function	cysteine-type endopeptidase activity
b	0006508	biological_process	proteolysis
b	0008234	molecular_function	cysteine-type peptidase activity
c	0004197	molecular_function	cysteine-type endopeptidase activity
c	0006508	biological_process	proteolysis
c	0008234	molecular_function	cysteine-type peptidase activity
d	0004197	molecular_function	cysteine-type endopeptidase activity
d	0006508	biological_process	proteolysis
d	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PROSITE/UniProt

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HkssdStfLvLMSHG

Chain	Residue	Details
A	HIS197-GLY211

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: (Microbial infection) ADP-riboxanated arginine => ECO:0000269|PubMed:34671164, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:36624349

Chain	Residue	Details
a	ARG314
b	ARG314
c	ARG314
d	ARG314

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: S-(2-succinyl)cysteine => ECO:0000269|PubMed:32820063

Chain	Residue	Details
D	ALA258
H	CYS309
H	CYS467
C	ALA258

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site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Cleavage; by autolysis => ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7797510

Chain	Residue	Details
A	ASP285
B	ASP285
C	ASP285
D	ASP285

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