6H2Q

Crystal Structure of Arg184Gln mutant of Human Prolidase with Mn ions and LeuPro ligand

Summary for 6H2Q

• Entry DOI: 10.2210/pdb6h2q/pdb
• Related: 5MC5 5mby 5mbz 5mc0 5mc1 5mc2 5mc3 5mc4
• Descriptor: Xaa-Pro dipeptidase, MANGANESE (II) ION, GLYCEROL, ... (6 entities in total)
• Functional Keywords: prolidase, peptidase, hydrolysis, pita-bread, metalloenzyme, mutation, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 110160.60

Authors

Wilk, P.,Piwowarczyk, R.,Weiss, M.S. (deposition date: 2018-07-14, release date: 2018-08-15, Last modification date: 2020-04-22)

• Primary citation: Wilk, P.,Uehlein, M.,Piwowarczyk, R.,Dobbek, H.,Mueller, U.,Weiss, M.S.; Structural basis for prolidase deficiency disease mechanisms.; FEBS J., 285:3422-3441, 2018; PubMed: 30066404; DOI: 10.1111/febs.14620

Experimental method

X-RAY DIFFRACTION (1.78 Å)