5MC1

Crystal Structure of Asp276Asn mutant of Human Prolidase with Mn ions and GlyPro ligand

Summary for 5MC1

• Entry DOI: 10.2210/pdb5mc1/pdb
• Related: 5M4J 5MBY 5MBZ 5MC0 5MC2 5MC3 5MC4 5MC5
• Descriptor: Xaa-Pro dipeptidase, MANGANESE (II) ION, SODIUM ION, ... (7 entities in total)
• Functional Keywords: prolidase, peptidase, hydrolysis, pita-bread, metalloenzyme, mutation, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 109250.56

Authors

Wilk, P.,Mueller, U.,Dobbek, H.,Weiss, M.S. (deposition date: 2016-11-09, release date: 2017-12-20, Last modification date: 2024-01-17)

• Primary citation: Wilk, P.,Uehlein, M.,Piwowarczyk, R.,Dobbek, H.,Mueller, U.,Weiss, M.S.; Structural basis for prolidase deficiency disease mechanisms.; FEBS J., 285:3422-3441, 2018; PubMed: 30066404; DOI: 10.1111/febs.14620

Experimental method

X-RAY DIFFRACTION (1.43 Å)