6DJ7

HIV-1 protease with mutation L76V in complex with GRL-5010 (gem-difluoro-bis-tetrahydrofuran as P2 ligand)

Summary for 6DJ7

• Entry DOI: 10.2210/pdb6dj7/pdb
• Related: 2IEN
• Descriptor: HIV-1 protease, SODIUM ION, CHLORIDE ION, ... (7 entities in total)
• Functional Keywords: antiviral agents, hiv drug resistance, antiviral protein, hydrolase
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22468.57

Authors

Wong-Sam, A.E.,Wang, Y.F.,Weber, I.T. (deposition date: 2018-05-24, release date: 2018-10-17, Last modification date: 2023-10-11)

• Primary citation: Wong-Sam, A.,Wang, Y.F.,Zhang, Y.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T.; Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease.; ACS Omega, 3:12132-12140, 2018; PubMed: 30288468; DOI: 10.1021/acsomega.8b01683

Experimental method

X-RAY DIFFRACTION (1.31 Å)