Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 501 |
| Chain | Residue |
| A | ASP60 |
| A | HOH619 |
| A | HOH629 |
| A | HOH639 |
| A | HOH648 |
| A | HOH661 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 502 |
| Chain | Residue |
| A | THR74 |
| A | ASN88 |
| B | ARG41 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | LYS55 |
| A | HOH645 |
| B | ILE63 |
| site_id | AC4 |
| Number of Residues | 32 |
| Details | binding site for residue G10 B 201 |
| Chain | Residue |
| A | LEU23 |
| A | ASP25 |
| A | GLY27 |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | VAL32 |
| A | GLY48 |
| A | GLY49 |
| A | ILE50 |
| A | PRO81 |
| A | VAL82 |
| A | ILE84 |
| A | HOH602 |
| A | HOH618 |
| B | ARG8 |
| B | LEU23 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP29 |
| B | ASP30 |
| B | VAL32 |
| B | GLY48 |
| B | GLY49 |
| B | ILE50 |
| B | PRO81 |
| B | ILE84 |
| B | HOH312 |
| B | HOH324 |
| B | HOH366 |
| B | HOH385 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 202 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 203 |
| Chain | Residue |
| B | THR74 |
| B | ASN88 |
| B | HOH345 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 204 |
| Chain | Residue |
| A | GLN18 |
| A | MET36 |
| A | SER37 |
| B | THR12 |
| B | GLU65 |
| B | ALA67 |
| B | GLY68 |
| B | HOH352 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 205 |
| Chain | Residue |
| B | PRO39 |
| B | GLY40 |
| B | ARG41 |
| B | TYR59 |
| B | ASP60 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 206 |
| Chain | Residue |
| B | THR4 |
| B | PRO44 |
| B | CL202 |
| B | HOH313 |
| B | HOH381 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI |
| Chain | Residue | Details |
| A | ALA22-ILE33 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ASP25 | |
| B | ASP25 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by viral protease => ECO:0000250 |
| Chain | Residue | Details |
| A | PHE99 | |
| B | PHE99 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 175 |
| Chain | Residue | Details |
| A | ASP25 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | THR26 | electrostatic stabiliser, transition state stabiliser |
| A | GLY27 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 175 |
| Chain | Residue | Details |
| B | ASP25 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | THR26 | electrostatic stabiliser, transition state stabiliser |
| B | GLY27 | electrostatic stabiliser, hydrogen bond donor |
