6CZC
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with thymidine triphosphate (TTP) - promiscuous binding mode with disordered nucleoside
Summary for 6CZC
Entry DOI | 10.2210/pdb6czc/pdb |
Related | 3FGN 3FMF 3FMI 3FPA 4WOP 6CVE 6CVF 6CVU 6CVV 6CZB 6CZD 6CZE |
Descriptor | ATP-dependent dethiobiotin synthetase BioD, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | enzyme, synthetase, nucleotide triphosphate binding, transferase |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 4 |
Total formula weight | 95921.55 |
Authors | Thompson, A.P.,Wegener, K.L.,Bruning, J.B.,Polyak, S.W. (deposition date: 2018-04-09, release date: 2018-11-21, Last modification date: 2024-03-13) |
Primary citation | Thompson, A.P.,Salaemae, W.,Pederick, J.L.,Abell, A.D.,Booker, G.W.,Bruning, J.B.,Polyak, S.W. Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes Acs Catalysis, 8(11):10774-10783, 2018 Cited by DOI: 10.1021/acscatal.8b03475PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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