6CH4

Aminoglycoside Phosphotransferase (2'')-Ia S376N mutant in complex with GMPPNP and Magnesium

Summary for 6CH4

Entry DOI	10.2210/pdb6ch4/pdb
Related	6C5U 6CAV 6CEY 6CGD 6CGG
Descriptor	Bifunctional AAC/APH, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	kinase, antibiotic, aminoglycoside, resistance, transferase, transferase-antibiotic complex
Biological source	Staphylococcus aureus
Total number of polymer chains	4
Total formula weight	146266.17
Authors	Caldwell, S.J.,Berghuis, A.M. (deposition date: 2018-02-21, release date: 2018-04-11, Last modification date: 2023-10-04)
Primary citation	Caldwell, S.J.,Berghuis, A.M. Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2′′)-Ia. Antimicrob. Agents Chemother., 62:-, 2018 Cited by PubMed: 29661878 DOI: 10.1128/AAC.00202-18 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation