6BBE

Structure of N-glycosylated porcine surfactant protein-D

Summary for 6BBE

• Entry DOI: 10.2210/pdb6bbe/pdb
• Related: 4DN8
• Descriptor: Pulmonary surfactant-associated protein D, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: innate immunity, surfactant, n-linked glycan, c-type lectin, surfactant protein
• Biological source: Sus scrofa (Pig)
• Total number of polymer chains: 1
• Total formula weight: 18693.64

Authors

van Eijk, M.,Rynkiewicz, M.J.,Khatri, K.,Leymarie, N.,Zaia, J.,White, M.R.,Hartshorn, K.L.,Cafarella, T.R.,van Die, I.,Hessing, M.,Seaton, B.A.,Haagsman, H.P. (deposition date: 2017-10-18, release date: 2018-05-23, Last modification date: 2021-03-24)

• Primary citation: van Eijk, M.,Rynkiewicz, M.J.,Khatri, K.,Leymarie, N.,Zaia, J.,White, M.R.,Hartshorn, K.L.,Cafarella, T.R.,van Die, I.,Hessing, M.,Seaton, B.A.,Haagsman, H.P.; Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus.; J. Biol. Chem., 293:10646-10662, 2018; PubMed: 29769321; DOI: 10.1074/jbc.RA117.001430

Experimental method

X-RAY DIFFRACTION (1.898 Å)