6AY5
CREBBP bromodomain in complex with Cpd17 (5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-3-methylbenzo[d]thiazol-2(3H)-one)
Summary for 6AY5
Entry DOI | 10.2210/pdb6ay5/pdb |
Related | 6AXQ 6AY3 |
Descriptor | CREB-binding protein, 5-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-3-methyl-1,3-benzothiazol-2(3H)-one, SULFATE ION, ... (6 entities in total) |
Functional Keywords | crebbp, bromodomain, sbdd, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q92793 |
Total number of polymer chains | 1 |
Total formula weight | 14507.54 |
Authors | Murray, J.M. (deposition date: 2017-09-07, release date: 2018-02-21, Last modification date: 2023-10-04) |
Primary citation | Bronner, S.M.,Murray, J.,Romero, F.A.,Lai, K.W.,Tsui, V.,Cyr, P.,Beresini, M.H.,de Leon Boenig, G.,Chen, Z.,Choo, E.F.,Clark, K.R.,Crawford, T.D.,Jayaram, H.,Kaufman, S.,Li, R.,Li, Y.,Liao, J.,Liang, X.,Liu, W.,Ly, J.,Maher, J.,Wai, J.,Wang, F.,Zheng, A.,Zhu, X.,Magnuson, S. A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors. J. Med. Chem., 60:10151-10171, 2017 Cited by PubMed: 29155580DOI: 10.1021/acs.jmedchem.7b01372 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.44 Å) |
Structure validation
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