6AXQ

CREBBP bromodomain in complex with Cpd6 (methyl 1H-indole-3-carboxylate)

Summary for 6AXQ

Entry DOI	10.2210/pdb6axq/pdb
Related	6AY3 6AY5
Descriptor	CREB-binding protein, DIMETHYL SULFOXIDE, methyl 1H-indole-3-carboxylate, ... (4 entities in total)
Functional Keywords	crebbp, bromodomain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q92793
Total number of polymer chains	4
Total formula weight	55415.41
Authors	Murray, J.M.,Jayaram, H. (deposition date: 2017-09-07, release date: 2018-02-21, Last modification date: 2023-10-04)
Primary citation	Bronner, S.M.,Murray, J.,Romero, F.A.,Lai, K.W.,Tsui, V.,Cyr, P.,Beresini, M.H.,de Leon Boenig, G.,Chen, Z.,Choo, E.F.,Clark, K.R.,Crawford, T.D.,Jayaram, H.,Kaufman, S.,Li, R.,Li, Y.,Liao, J.,Liang, X.,Liu, W.,Ly, J.,Maher, J.,Wai, J.,Wang, F.,Zheng, A.,Zhu, X.,Magnuson, S. A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors. J. Med. Chem., 60:10151-10171, 2017 Cited by PubMed: 29155580 DOI: 10.1021/acs.jmedchem.7b01372 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation