5X23
Crystal structure of CYP2C9 genetic variant A477T (*30) in complex with multiple losartan molecules
Summary for 5X23
Entry DOI | 10.2210/pdb5x23/pdb |
Related | 5X24 |
Descriptor | Cytochrome P450 2C9, PROTOPORPHYRIN IX CONTAINING FE, [2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol, ... (6 entities in total) |
Functional Keywords | oxidoreductase, cyp2c9 polymorphic mutant, single nucleotide polymorphism, p450 2c9 genetic variant |
Biological source | Homo sapiens (Human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P11712 |
Total number of polymer chains | 1 |
Total formula weight | 56285.13 |
Authors | Maekawa, K.,Adachi, M.,Shah, M.B. (deposition date: 2017-01-30, release date: 2017-10-25, Last modification date: 2023-11-22) |
Primary citation | Maekawa, K.,Adachi, M.,Matsuzawa, Y.,Zhang, Q.,Kuroki, R.,Saito, Y.,Shah, M.B. Structural Basis of Single-Nucleotide Polymorphisms in Cytochrome P450 2C9 Biochemistry, 56:5476-5480, 2017 Cited by PubMed: 28972767DOI: 10.1021/acs.biochem.7b00795 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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