5X24

Crystal structure of CYP2C9 genetic variant I359L (*3) in complex with multiple losartan molecules

Summary for 5X24

Entry DOI	10.2210/pdb5x24/pdb
Related	5X23
Descriptor	Cytochrome P450 2C9, PROTOPORPHYRIN IX CONTAINING FE, [2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol, ... (6 entities in total)
Functional Keywords	oxidoreductase, cyp2c9 polymorphic mutant, single nucleotide polymorphism, p450 2c9 genetic variant
Biological source	Homo sapiens (Human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P11712
Total number of polymer chains	1
Total formula weight	55832.19
Authors	Maekawa, K.,Adachi, M.,Shah, M.B. (deposition date: 2017-01-30, release date: 2017-10-25, Last modification date: 2023-11-22)
Primary citation	Maekawa, K.,Adachi, M.,Matsuzawa, Y.,Zhang, Q.,Kuroki, R.,Saito, Y.,Shah, M.B. Structural Basis of Single-Nucleotide Polymorphisms in Cytochrome P450 2C9 Biochemistry, 56:5476-5480, 2017 Cited by PubMed: 28972767 DOI: 10.1021/acs.biochem.7b00795 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.48 Å)

Structure validation