5VL3
CD22 d1-d3 in complex with therapeutic Fab Epratuzumab
Summary for 5VL3
Entry DOI | 10.2210/pdb5vl3/pdb |
Related | 5VKJ 5VKK 5VKM |
EMDB information | 8704 8705 |
Descriptor | B-cell receptor CD22, Epratuzumab Fab Heavy Chain, Epratuzumab Fab Light Chain, ... (8 entities in total) |
Functional Keywords | therapeutic antibody, siglec, b cell, fab, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 345472.70 |
Authors | Sicard, T.,Ereno-Orbea, J.,Julien, J.P. (deposition date: 2017-04-24, release date: 2017-10-11, Last modification date: 2020-07-29) |
Primary citation | Ereno-Orbea, J.,Sicard, T.,Cui, H.,Mazhab-Jafari, M.T.,Benlekbir, S.,Guarne, A.,Rubinstein, J.L.,Julien, J.P. Molecular basis of human CD22 function and therapeutic targeting. Nat Commun, 8:764-764, 2017 Cited by PubMed: 28970495DOI: 10.1038/s41467-017-00836-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
Download full validation report