5UZK
Crystal Structure of PKA bound to an pyrrolo pyridine inhibitor
Summary for 5UZK
Entry DOI | 10.2210/pdb5uzk/pdb |
Related | 5UZJ |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 2-{3-[3-(piperidin-4-yl)propoxy]phenyl}-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide, ... (4 entities in total) |
Functional Keywords | phosphorylation, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 43257.35 |
Authors | Jacobs, M.D.,Brown, K. (deposition date: 2017-02-26, release date: 2018-03-07, Last modification date: 2023-10-04) |
Primary citation | Bandarage, U.K.,Cao, J.,Come, J.H.,Court, J.J.,Gao, H.,Jacobs, M.D.,Marhefka, C.,Nanthakumar, S.,Green, J. ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors. Bioorg. Med. Chem. Lett., 28:2622-2626, 2018 Cited by PubMed: 30082069DOI: 10.1016/j.bmcl.2018.06.040 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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