5UZK

Crystal Structure of PKA bound to an pyrrolo pyridine inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	cAMP-dependent protein kinase catalytic subunit alpha	polymer	351	40808.6	1	UniProt (P17612) Pfam (PF00069) In PDB	Homo sapiens (Human)	PKA C-alpha
2	I	cAMP-dependent protein kinase inhibitor alpha	polymer	18	1973.2	1	UniProt (P61926) In PDB	Oryctolagus cuniculus	PKI-alpha,cAMP-dependent protein kinase inhibitor,muscle/brain isoform
3	A	2-{3-[3-(piperidin-4-yl)propoxy]phenyl}-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	non-polymer		475.6	1	Chemie (504)
4		water	water		18.0	275	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	42781.7
Non-Polymers*	Number of molecules	1
	Total formula weight	475.6
All*	Total formula weight	43257.4

*Water molecules are not included.