5TTW

Crystal Structure of EED in Complex with UNC4859

Summary for 5TTW

• Entry DOI: 10.2210/pdb5ttw/pdb
• Related: 3K26
• Descriptor: Polycomb protein EED, UNC4859, SULFATE ION, ... (5 entities in total)
• Functional Keywords: wd40, eed peptide inhibitor, transcription regulator-inhibitor complex, transcription regulator/inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus: O75530
• Total number of polymer chains: 4
• Total formula weight: 86170.25

Authors

The, J.,Barnash, K.D.,Brown, P.J.,Edwards, A.M.,Bountra, C.,Frye, S.V.,James, L.I.,Arrowsmith, C.H. (deposition date: 2016-11-04, release date: 2017-01-11, Last modification date: 2023-10-04)

• Primary citation: Barnash, K.D.,The, J.,Norris-Drouin, J.L.,Cholensky, S.H.,Worley, B.M.,Li, F.,Stuckey, J.I.,Brown, P.J.,Vedadi, M.,Arrowsmith, C.H.,Frye, S.V.,James, L.I.; Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.; ACS Comb Sci, 19:161-172, 2017; PubMed: 28165227; DOI: 10.1021/acscombsci.6b00174

Experimental method

X-RAY DIFFRACTION (1.74 Å)