5TO3

Crystal structure of thrombin mutant W215A/E217A fused to EGF456 of thrombomodulin via a 31-residue linker and bound to PPACK

Summary for 5TO3

• Entry DOI: 10.2210/pdb5to3/pdb
• Related: 1DX5
• Related PRD ID: PRD_000020
• Descriptor: Prothrombin, Prothrombin,Thrombomodulin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: hydrolase, autoactivation, thrombin-thrombomodulin fusion protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 52180.71

Authors

Barranco-Medina, S.,Murphy, M.,Pelc, L.,Chen, Z.,Di Cera, E.,Pozzi, N. (deposition date: 2016-10-16, release date: 2017-03-29, Last modification date: 2023-10-04)

• Primary citation: Barranco-Medina, S.,Murphy, M.,Pelc, L.,Chen, Z.,Di Cera, E.,Pozzi, N.; Rational Design of Protein C Activators.; Sci Rep, 7:44596-44596, 2017; PubMed: 28294177; DOI: 10.1038/srep44596

Experimental method

X-RAY DIFFRACTION (2.34 Å)