5TFT

Structure of cytochrome P450 2D6 (CYP2D6) BACE1 inhibitor complex

5TFT の概要

• エントリーDOI: 10.2210/pdb5tft/pdb
• 関連するPDBエントリー: 5T1U 5TFT
• 分子名称: Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, ZINC ION, ... (5 entities in total)
• 機能のキーワード: cyp2d6, p450 2d6, cytochrome p450, monooxygenase, bace1, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 219232.82

構造登録者

Hsu, M.H.,Johnson, E.F. (登録日: 2016-09-26, 公開日: 2017-01-11, 最終更新日: 2023-10-04)

• 主引用文献: Butler, C.R.,Ogilvie, K.,Martinez-Alsina, L.,Barreiro, G.,Beck, E.M.,Nolan, C.E.,Atchison, K.,Benvenuti, E.,Buzon, L.,Doran, S.,Gonzales, C.,Helal, C.J.,Hou, X.,Hsu, M.H.,Johnson, E.F.,Lapham, K.,Lanyon, L.,Parris, K.,O'Neill, B.T.,Riddell, D.,Robshaw, A.,Vajdos, F.,Brodney, M.A.; Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.; J. Med. Chem., 60:386-402, 2017; PubMed: 27997172; DOI: 10.1021/acs.jmedchem.6b01451

実験手法

X-RAY DIFFRACTION (2.71 Å)