5T4S

Novel Approach of Fragment-Based Lead Discovery applied to Renin Inhibitors

Summary for 5T4S

Entry DOI	10.2210/pdb5t4s/pdb
Descriptor	Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, ... (7 entities in total)
Functional Keywords	protein-ligand complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P00797
Total number of polymer chains	2
Total formula weight	75532.52
Authors	Snell, G.P.,Behnke, C.A.,Okada, K.,Oki, H.,Sang, B.C.,Lane, W. (deposition date: 2016-08-30, release date: 2016-10-26, Last modification date: 2020-07-29)
Primary citation	Tawada, M.,Suzuki, S.,Imaeda, Y.,Oki, H.,Snell, G.,Behnke, C.A.,Kondo, M.,Tarui, N.,Tanaka, T.,Kuroita, T.,Tomimoto, M. Novel approach of fragment-based lead discovery applied to renin inhibitors. Bioorg.Med.Chem., 24:6066-6074, 2016 Cited by PubMed: 27720325 DOI: 10.1016/j.bmc.2016.09.065 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.64 Å)

Structure validation