5OX5

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with CCT6, a GSK1278863-related compound

Summary for 5OX5

• Entry DOI: 10.2210/pdb5ox5/pdb
• Descriptor: Egl nine homolog 1, MANGANESE (II) ION, (6-hydroxy-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl)glycine, ... (5 entities in total)
• Functional Keywords: oxidoreductase, non-heme dioxygenase, iron, 2-oxoglutarate, hypoxia-inducible factor, hif, hif prolyl hydroxylase domain 2, phd2, egln1, oxygenase, hypoxia, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, cytoplasm, transcription/epigenetic regulation, signaling, development, cell structure, beta-hydroxylation, transcription activator/inhibitor, ubl conjugation, polymorphism, vitamin c, zinc-finger, familial erythrocytosis, breast cancer, transcription complex
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : Q9GZT9
• Total number of polymer chains: 1
• Total formula weight: 28470.10

Authors

Chowdhury, R.,Thinnes, C.C.,Schofield, C.J. (deposition date: 2017-09-06, release date: 2017-10-18, Last modification date: 2024-01-17)

• Primary citation: Yeh, T.L.,Leissing, T.M.,Abboud, M.I.,Thinnes, C.C.,Atasoylu, O.,Holt-Martyn, J.P.,Zhang, D.,Tumber, A.,Lippl, K.,Lohans, C.T.,Leung, I.K.H.,Morcrette, H.,Clifton, I.J.,Claridge, T.D.W.,Kawamura, A.,Flashman, E.,Lu, X.,Ratcliffe, P.J.,Chowdhury, R.,Pugh, C.W.,Schofield, C.J.; Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.; Chem Sci, 8:7651-7668, 2017; PubMed: 29435217; DOI: 10.1039/c7sc02103h

Experimental method

X-RAY DIFFRACTION (2.251 Å)