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5M7T

Structure of human O-GlcNAc hydrolase with PugNAc type inhibitor

Summary for 5M7T
Entry DOI10.2210/pdb5m7t/pdb
DescriptorProtein O-GlcNAcase, (5R,6R,7R,8S)-8-(ACETYLAMINO)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-N-PHENYL-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXAMIDE (2 entities in total)
Functional Keywordshuman glacoside hydrolase, glcnac, hydrolase
Biological sourceHomo sapiens (Human)
Cellular locationIsoform 3: Nucleus . Isoform 1: Cytoplasm : O60502
Total number of polymer chains2
Total formula weight206764.56
Authors
Roth, C.,Chan, S.,Offen, W.A.,Hemsworth, G.R.,Willems, L.I.,King, D.,Varghese, V.,Britton, R.,Vocadlo, D.J.,Davies, G.J. (deposition date: 2016-10-28, release date: 2017-03-29, Last modification date: 2017-08-30)
Primary citationRoth, C.,Chan, S.,Offen, W.A.,Hemsworth, G.R.,Willems, L.I.,King, D.T.,Varghese, V.,Britton, R.,Vocadlo, D.J.,Davies, G.J.
Structural and functional insight into human O-GlcNAcase.
Nat. Chem. Biol., 13:610-612, 2017
Cited by
PubMed: 28346405
DOI: 10.1038/nchembio.2358
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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