5M7T

Structure of human O-GlcNAc hydrolase with PugNAc type inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004415	molecular_function	hyalurononglucosaminidase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006044	biological_process	N-acetylglucosamine metabolic process
A	0006493	biological_process	protein O-linked glycosylation
A	0006516	biological_process	glycoprotein catabolic process
A	0006517	biological_process	protein deglycosylation
A	0008152	biological_process	metabolic process
A	0009100	biological_process	glycoprotein metabolic process
A	0016020	cellular_component	membrane
A	0016231	molecular_function	beta-N-acetylglucosaminidase activity
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0042802	molecular_function	identical protein binding
A	0102166	molecular_function	obsolete [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity
A	0102167	molecular_function	obsolete [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity
A	0102571	molecular_function	[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
A	1901135	biological_process	carbohydrate derivative metabolic process
B	0004415	molecular_function	hyalurononglucosaminidase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006044	biological_process	N-acetylglucosamine metabolic process
B	0006493	biological_process	protein O-linked glycosylation
B	0006516	biological_process	glycoprotein catabolic process
B	0006517	biological_process	protein deglycosylation
B	0008152	biological_process	metabolic process
B	0009100	biological_process	glycoprotein metabolic process
B	0016020	cellular_component	membrane
B	0016231	molecular_function	beta-N-acetylglucosaminidase activity
B	0016787	molecular_function	hydrolase activity
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0042802	molecular_function	identical protein binding
B	0102166	molecular_function	obsolete [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity
B	0102167	molecular_function	obsolete [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity
B	0102571	molecular_function	[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
B	1901135	biological_process	carbohydrate derivative metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue GDV A 1001

Chain	Residue
A	GLY67
A	ASN280
A	ASP285
A	ASN313
A	PHE68
A	LYS98
A	ASP174
A	ASP175
A	TYR219
A	PHE223
A	VAL254
A	TRP278

---

site_id	AC2
Number of Residues	11
Details	binding site for residue GDV B 1001

Chain	Residue
B	GLY67
B	PHE68
B	LYS98
B	ASP174
B	ASP175
B	TYR219
B	VAL254
B	TRP278
B	ASN280
B	ASP285
B	ASN313

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01353, ECO:0000305|PubMed:16533067

Chain	Residue	Details
A	ASP175
B	ASP175

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site_id	SWS_FT_FI2
Number of Residues	14
Details	BINDING: BINDING => ECO:0000269|PubMed:28939839, ECO:0007744|PDB:5VVT

Chain	Residue	Details
A	GLY67
B	ASP174
B	ASP175
B	TYR219
B	ASP285
B	ASN313
A	LYS98
A	ASP174
A	ASP175
A	TYR219
A	ASP285
A	ASN313
B	GLY67
B	LYS98

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Cleavage; by caspase-3 => ECO:0000269|PubMed:18586680

Chain	Residue	Details
A	ASP413
B	ASP413

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER364
B	SER364

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