5KYA
Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core
Summary for 5KYA
Entry DOI | 10.2210/pdb5kya/pdb |
Related | 5I4V |
Descriptor | Oxysterols receptor LXR-beta, Retinoic acid receptor RXR-beta, [2-[(6~{R})-2-(3-methylsulfonylphenyl)-6-propan-2-yl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-4-(trifluoromethyl)pyrimidin-5-yl]methanol, ... (4 entities in total) |
Functional Keywords | nuclear receptor, liver x receptor, lxrbeta-lbd/rxrbeta-lbd heterodimer, chemical modulators, dna binding protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : P55055 P28702 |
Total number of polymer chains | 4 |
Total formula weight | 122381.92 |
Authors | Chen, G.,McKeever, B.M. (deposition date: 2016-07-21, release date: 2016-09-21, Last modification date: 2024-03-06) |
Primary citation | Tice, C.M.,Noto, P.B.,Fan, K.Y.,Zhao, W.,Lotesta, S.D.,Dong, C.,Marcus, A.P.,Zheng, Y.J.,Chen, G.,Wu, Z.,Van Orden, R.,Zhou, J.,Bukhtiyarov, Y.,Zhao, Y.,Lipinski, K.,Howard, L.,Guo, J.,Kandpal, G.,Meng, S.,Hardy, A.,Krosky, P.,Gregg, R.E.,Leftheris, K.,McKeever, B.M.,Singh, S.B.,Lala, D.,McGeehan, G.M.,Zhuang, L.,Claremon, D.A. Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core. Bioorg.Med.Chem.Lett., 26:5044-5050, 2016 Cited by PubMed: 27599745DOI: 10.1016/j.bmcl.2016.08.089 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.598 Å) |
Structure validation
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