5I4V

Discovery of novel, orally efficacious Liver X Receptor (LXR) beta agonists

Summary for 5I4V

Entry DOI	10.2210/pdb5i4v/pdb
Descriptor	Oxysterols receptor LXR-beta,Nuclear receptor coactivator 2, Retinoic acid receptor RXR-beta,Nuclear receptor coactivator 2, {2-[(2R)-4-[4-(hydroxymethyl)-3-(methylsulfonyl)phenyl]-2-(propan-2-yl)piperazin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanol, ... (4 entities in total)
Functional Keywords	lxrbeta-lbd, rxrbeta-lbd, heterodimer, agonist, dna binding protein
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus: Q15596 Q15596
Total number of polymer chains	4
Total formula weight	118341.54
Authors	Chen, G.,McKeever, B.M. (deposition date: 2016-02-12, release date: 2016-06-29, Last modification date: 2023-09-27)
Primary citation	Zheng, Y.,Zhuang, L.,Fan, K.Y.,Tice, C.M.,Zhao, W.,Dong, C.,Lotesta, S.D.,Leftheris, K.,Lindblom, P.R.,Liu, Z.,Shimada, J.,Noto, P.B.,Meng, S.,Hardy, A.,Howard, L.,Krosky, P.,Guo, J.,Lipinski, K.,Kandpal, G.,Bukhtiyarov, Y.,Zhao, Y.,Lala, D.,Van Orden, R.,Zhou, J.,Chen, G.,Wu, Z.,McKeever, B.M.,McGeehan, G.M.,Gregg, R.E.,Claremon, D.A.,Singh, S.B. Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) beta Agonist. J.Med.Chem., 59:3264-3271, 2016 Cited by PubMed: 26990539 DOI: 10.1021/acs.jmedchem.5b02029 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.61 Å)

Structure validation