5KNX

Crystal structure of E. coli hypoxanthine phosphoribosyltransferase in complexed with {[(2-[(Hypoxanthin-9H-yl)methyl]propane-1,3-diyl)bis(oxy)]bis- (methylene)}diphosphonic Acid

Summary for 5KNX

Entry DOI	10.2210/pdb5knx/pdb
Related	5KNP 5KNQ 5KNR 5KNS 5KNT 5KNU 5KNV 5KNY
Descriptor	Hypoxanthine-guanine phosphoribosyltransferase, [2-[(6-oxidanylidene-1~{H}-purin-9-yl)methyl]-3-(phosphonomethoxy)propoxy]methylphosphonic acid, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	acyclic nucleoside phosphonate, echprt, phosphoribosyltransferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	42185.09
Authors	Eng, W.S.,Keough, D.T.,Hockova, D.,Janeba, Z.,Guddat, L.W. (deposition date: 2016-06-28, release date: 2017-07-19, Last modification date: 2024-03-06)
Primary citation	Eng, W.S.,Hockova, D.,Spacek, P.,Baszczynski, O.,Janeba, Z.,Naesens, L.,Keough, D.T.,Guddat, L.W. Crystal Structures of Acyclic Nucleoside Phosphonates in Complex with Escherichia coli Hypoxanthine Phosphoribosyltransferase Chemistryselect, 1:6267-6276, 2016 Cited by DOI: 10.1002/slct.201601679 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation