5KNT

Crystal structure of E. coli hypoxanthine phosphoribosyltransferase in complexed with 2-((2,3-Dihydroxypropyl)(2-(hypoxanthin-9-yl)ethyl)amino)ethylphosphonic acid

Summary for 5KNT

Entry DOI	10.2210/pdb5knt/pdb
Related	5KNP 5KNQ 5KNR 5KNS 5KNU 5KNV 5KNX 5KNY
Descriptor	Hypoxanthine-guanine phosphoribosyltransferase, 2-[[(2~{S})-2,3-bis(oxidanyl)propyl]-[2-(6-oxidanylidene-1~{H}-purin-9-yl)ethyl]amino]ethylphosphonic acid, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	acyclic nucleoside phosphonate, echprt, phosphoribosyltransferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	42272.91
Authors	Eng, W.S.,Keough, D.T.,Hockova, D.,Janeba, Z. (deposition date: 2016-06-28, release date: 2017-07-19, Last modification date: 2023-09-27)
Primary citation	Eng, W.S.,Hockova, D.,Spacek, P.,Baszczynski, O.,Janeba, Z.,Naesens, L.,Keough, D.T.,Guddat, L.W. Crystal Structures of Acyclic Nucleoside Phosphonates in Complex with Escherichia coli Hypoxanthine Phosphoribosyltransferase Chemistryselect, 1:6267-6276, 2016 Cited by DOI: 10.1002/slct.201601679 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation